The regiospecific Fischer indole reaction in choline chloride·2ZnCl_2 with product isolation by direct sublimation from the ionic liquid

摘要

The Fischer indole synthesis occurs in high yield with one equivalent of the ionic liquid choline chloride·2ZnCl_2; exclusive formation of 2,3-disubstituted indoles is observed in the reaction of alkyl methyl ketones, and the products readily sublime directly from the ionic liquid.