First synthesis of an amythiamicin pyridine cluster

Mark C. Bagley; James W. Dale; Robert L. Jenkins; Justin Bower

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First synthesis of an amythiamicin pyridine cluster

机译：霉菌素吡啶簇的首次合成

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The pyridine-containing central domain of the amythiamicin group of thiopeptide antibiotics is prepared in protected form in 9 steps, 93% ee and 18% overall yield from (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]thiazole-4-carboxylic acid by Michael addition-cyclodehydration of a 2-(2-thiazol-yl)enamine and 1-(2-thiazolyl)propynone.

机译：以9步，93％ee和18％的总收率从（S）-2- [1-（叔-丁氧基羰基氨基）-2-甲基丙基]制备受保护形式的硫肽抗生素的霉菌素基团的含吡啶中心结构域2-（2-噻唑基）烯胺和1-（2-噻唑基）丙炔酮的迈克尔加成环脱水制得噻唑-4-甲酸。

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来源
《Chemical Communications》 |2004年第1期|p.102-103|共2页
作者
Mark C. Bagley; James W. Dale; Robert L. Jenkins; Justin Bower;
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School of Chemistry, Cardiff University, PO Box 912, Cardiff, UK CF10 3TB;

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正文语种 eng
中图分类化学;
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入库时间 2022-08-17 13:33:03

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1. Total Synthesis of the Thiopeptide Antibiotic Amythiamicin D [J] . Rachael A.Hughes, Stewart P.Thompson, Lilian Alcaraz, Journal of the American Chemical Society . 2005,第44期

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6. Identification by Genome Mining of a Type I Polyketide Gene Cluster from Streptomyces argillaceus Involved in the Biosynthesis of Pyridine and Piperidine Alkaloids Argimycins P [O] . Suhui Ye, Brian Molloy, Alfredo F. Braña, -1

机译：通过基因组挖掘从涉及链霉菌素和哌啶生物碱Argymycins P的精链霉菌的I型聚酮基因簇进行鉴定
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First synthesis of an amythiamicin pyridine cluster

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