One-pot synthesis of benzolactones and lactams via a cobalt-catalyzed regioselective [2 + 2 + 2] cocyclotrimerization of alkynyl alcohols and amines with propiolates

摘要

An efficient method for the synthesis of benzolactones and benzolactams via a cobalt-catalyzed [2 + 2 + 2] cocyclotrimerization of alkynyl alcohols and alkynyl amines with propiolates is described.The transition metal catalyzed [2 + 2 + 2] cycloaddition reaction of unsaturated molecules is an efficient method to construct six-membered cyclic compounds with the formation of three new carbon-carbon bonds.