Synthesis of tetrahydropyrimidin-2-ones via FeCl_3 catalyzed one-pot domino reaction of amines, methyl propiolate, aromatic aldehydes, and urea

摘要

Polysubstituted 3-arylaminoacrylate and tetrahydropyrimidin-2-one derivatives could be selectively produced from the one-pot domino reaction of arylamines, methyl propiolate, aromatic aldehydes, and urea in ethanol in the presence of FeCl_3 as catalyst. Under similar reactions secondary amines such as morpholine and piperidine predominately afford tetrahydropyrimidin-2-one derivatives in good yields.