Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support

摘要

By relying on asymmetric boron-mediated aldol reactions,solid phase methodology for the stereoselective synthesis of highly substituted spiroacetals was developed and applied to the preparation of a complex AB-spiroacetal subunit of the antimitotic agent spongistatin 1 (altohyrtin A).