A zinc(Ⅱ)-based receptor for ATP binding and hydrolysis

Carla Bazzicalupi; Andrea Bencini; Antonio Bianchi; Andrea Danesi; Claudia Giorgi; Carlos Lodeiro; Fernando Pina; Samuele Santarelli; Barbara Valtancoli

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A zinc(Ⅱ)-based receptor for ATP binding and hydrolysis

机译：基于锌（Ⅱ）的ATP结合和水解受体

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A protonated Zn(Ⅱ) complex with a terpyridine-containing pentaamine macrocycle catalyses ATP hydrolysis in the presence of a second metal ion, which acts as cofactor assisting the phosphoryl transfer from ATP to an amine group of the receptor.

机译：质子化的Zn（Ⅱ）配合物与含三联吡啶的五胺大环化合物在第二金属离子存在下催化ATP水解，该金属离子作为辅助因子帮助磷酸从ATP转移至受体的胺基。

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来源
《Chemical Communications》 |2005年第20期|p.2630-2632|共3页
作者
Carla Bazzicalupi; Andrea Bencini; Antonio Bianchi; Andrea Danesi; Claudia Giorgi; Carlos Lodeiro; Fernando Pina; Samuele Santarelli; Barbara Valtancoli;
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作者单位

Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019-Sesto Fiorentino, Firenze, Italy;

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正文语种 eng
中图分类化学;
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入库时间 2022-08-17 13:31:33

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专利

1. The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: Evidence for a conserved subdomain, the A-loop in the ATP-binding cassette [J] . Kim IW, Peng XH, Sauna ZE, Biochemistry . 2006,第24期

机译：人P-糖蛋白ATP位点中保守的酪氨酸残基401和1044对于ATP结合和水解至关重要：保守的亚域的证据，即ATP结合盒中的A环
2. A Series of Oxyimine-Based Macrocyclic Dinuclear Zinc(II) Complexes Enhances Phosphate Ester Hydrolysis, DNA Binding, DNA Hydrolysis, and Lactate Dehydrogenase Inhibition and Induces Apoptosis [J] . Sellamuthu Anbu, † Subban Kamalraj, ‡ Babu Varghese, Inorganic Chemistry . 2012,第10期

机译：一系列基于氧胺的大环双核锌（II）复合物增强磷酸酯水解，DNA结合，DNA水解和乳酸脱氢酶抑制并诱导凋亡。
3. A series of oxyimine-based macrocyclic dinuclear zinc(II) complexes enhances phosphate ester hydrolysis, DNA binding, DNA hydrolysis, and lactate dehydrogenase inhibition and induces apoptosis [J] . Anbu S., Kamalraj S., Varghese B., Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2012,第10期

机译：一系列基于氧亚胺的大环双核锌（II）配合物可增强磷酸酯水解，DNA结合，DNA水解和乳酸脱氢酶抑制作用并诱导凋亡
4. MgATP BINDING AND HYDROLYSIS IN NITROGENASE CATALYSIS [C] . Sanchayita Sen, John W. Peters International Nitrogen Fixation Congress . 2005

机译：氮酶催化中的MgATP结合和水解
5. Biophysical characterization of zinc(II)-binding domains in two systems: Neural zinc finger factor-1 and T-cell co-receptors DC4 and DC8 alpha with T-cell-specific kinase Lck. [D] . Davis, Alisa M. 2007

机译：锌（II）结合域在两个系统中的生物物理特征：神经锌指因子1和T细胞共受体DC4和DC8α与T细胞特异性激酶Lck。
6. ATP binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate KATP channels [O] . Jelena Sikimic, Timothy S. McMillen, Cita Bleile, 2019

机译：无需水解的ATP结合将磺酰脲受体1（SUR1）切换为激活KATP通道的向外构象
7. ATP Binding to the First Nucleotide Binding Domain of Multidrug Resistance-associated Protein Plays a Regulatory Role at Low Nucleotide Concentration, whereas ATP Hydrolysis at the Second Plays a Dominant Role in ATP-dependent Leukotriene C4 Transport [O] . Runying Yang, Liying Cui, Yue-xian Hou, 2003

机译：ATP与多药抗性相关蛋白的第一核苷酸结合结构域的结合在低核苷酸浓度下起调节作用，而在第二次在ATP依赖性白酮C4运输中起显性作用

A zinc(Ⅱ)-based receptor for ATP binding and hydrolysis

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