Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications

摘要

The synthesis of a multifunctionally equipped first generation (Gl) dendrimer carrying a pentapeptide with a cathepsin B cleavage site,chelating ligands for Pt~(2+)-complexation,and a dansyl fluorescence marker is described and an investigation of its cellular uptake as well as intracellular localization by confocal fluorescence microscopy reported.