Luminescent cyclometalatcd platinum(Ⅱ) complexes with amino acid ligands for protein binding

摘要

Pt(C N)(phe) (1, C N = 2-(2′-thienyl)pyridine, phe = phenyl-alanine) shows a high binding affinity (ca. 10~6 dm~3 mol~(-1)) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photolumine-scence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C N)(phe) (1), Pt(C N)(trp) (2, tip = tryptophan) and Pt(C N)(gly) (3, gly = glycine)] are affected by the amino acid ligand with 1 having an IC_(50) of up to 1 μM against a number of carcinoma cell lines.