Design and synthesis of a new class of arginine analogues with an improved anion binding site in the side chain

摘要

Replacing the guanidinium group in arginine (1) by a guanidiniocarbonyl pyrrole moiety provides a new class of artificial amino acids (2),that can be used as building blocks in standard solid phase peptide synthesis.The natural amino acid arginine 1 is involved in many physiological and pathophysiological processes.