Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein

Reetz MT; Peyralans JJP; Maichele A; Fu Y; Maywald M

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Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein

机译：杂合酶的定向进化：锚定在蛋白质上的非手性Rh络合物的对映选择性的发展

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摘要

The concept of utilizing the methods of directed evolution for tuning the enantioselectivity of synthetic achiral metal - ligand centers anchored to proteins has been implemented experimentally for the first time.

机译：利用定向进化的方法来调节锚定在蛋白质上的合成非手性金属-配体中心的对映选择性的概念已首次通过实验实现。

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来源
《Chemical Communications》 |2006年第41期|p. 4318-4320|共3页
作者
Reetz MT; Peyralans JJP; Maichele A; Fu Y; Maywald M;
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作者单位

Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
METAL-BINDING SITES; ESCHERICHIA-COLI; ACTIVE-SITE; ASYMMETRIC HYDROGENATION; CHEMICAL-MODIFICATION; SECRETORY PRODUCTION; BACILLUS-SUBTILIS; STREPTAVIDIN; CATALYSTS; DESIGN;

机译：金属结合位;大肠埃希氏菌属;活性部位;不对称加氢;化学修饰;秘密生产;芽孢杆菌替代品;链霉抗生物素蛋白;催化剂;设计;

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专利

1. Directed Evolution of Enantioselective Enzymes: Iterative Cycles of CASTing for Probing Protein-Sequence Space [J] . Manfred T. Reetz, Li-Wen Wang, Marco Bocola Angewandte Chemie . 2006,第8期

机译：对映选择性酶的定向进化：探索蛋白质序列空间的CASTing的循环。
2. A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes [J] . Frédéric Cadet, Nicolas Fontaine, Guangyue Li, Scientific reports. . 2018,第1期

机译：一种可靠预测氨基酸相互作用的机器学习方法及其在对映选择性酶的定向进化中的应用
3. Directed evolution of enantioselective enzymes: An unceasing catalyst source for organic chemistry [J] . Reetz M.T., Wu S., Zheng H., Pure and Applied Chemistry . 2010,第8期

机译：对映选择性酶的定向进化：有机化学不断发展的催化剂来源
4. A NOVEL C-TERMINAL PROTEIN DEGRON IDENTIFIED IN BACTERIAL ALDEHYDE DECARBONYLASES USING DIRECTED ENZYME EVOLUTION [C] . Yilan Liu, Jinjin Chen, Anna Khusnutdinova, Conference on biochemical and molecular engineering . 2019

机译：利用直接酶进化法鉴定细菌醛类碳纳米管中的新C末端蛋白
5. Isobutene formation from 3-hydroxy-3-methylbutyrate (3-HMB) by the Saccharomyces cerevisiae diphosphomevalonate decarboxylase (ScMDD) and directed enzyme evolution to improve enzyme function. [D] . Gogerty, David. 2011

机译：酿酒酵母二磷酸甲戊二酸酯脱羧酶（ScMDD）由3-羟基-3-甲基丁酸酯（3-HMB）形成异丁烯，并指导酶进化以改善酶功能。
6. Asymmetric Catalysis Special Feature Part II: Controlling the enantioselectivity of enzymes by directed evolution: Practical and theoretical ramifications [O] . Manfred T. Reetz 2004

机译：不对称催化特征第二部分：通过定向进化控制酶的对映选择性：实践和理论上的分歧
7. Directed Evolution of Enantioselective Enzymes: Iterative Cycles of CASTing for Probing Protein-Sequence Space [O] . Manfred T. Reetz, Li-Wen Wang, Marco Bocola 2006

机译：对映选择性酶的定向演化：探测蛋白序列空间铸造迭代循环

Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein

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