The Morita-Baylis-Hillman adducts of beta-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies

Dadwal M; Mohan R; Panda D; Mobin SM; Namboothiri INN

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The Morita-Baylis-Hillman adducts of beta-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies

机译：β-芳基硝基乙烯与其他活化烯烃的Morita-Baylis-Hillman加合物：合成和抗癌活性研究

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摘要

The Morita-Baylis-Hillman (MBH) adducts of beta-aryl nitroethylenes with methyl vinyl ketone (MVK) and acrylate, formed in moderate to good yield when mediated by imidazole/LiCl in THF at room temperature, inhibit HeLa cell prolifieration by binding to tubulin.

机译：β-芳基硝基乙烯与甲基乙烯基酮（MVK）和丙烯酸酯的Morita-Baylis-Hillman（MBH）加合物，在室温下由咪唑/ LiCl介导于THF中时，生成的产率中等至良好，可抑制HeLa细胞增殖微管蛋白。

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来源
《Chemical Communications》 |2006年第3期|p. 338-340|共3页
作者
Dadwal M; Mohan R; Panda D; Mobin SM; Namboothiri INN;
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作者单位

Indian Inst Technol, Sch Biosci & Bioengn, Bombay 400076, Maharashtra, India;

Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India;

Indian Inst Technol, Natl Single Crystal Xray Diffract Facil, Bombay 400076, Maharashtra, India;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
DABCO-CATALYZED DIMERIZATION; MICROTUBULE POLYMERIZATION; CONJUGATED NITROALKENES; RATE ACCELERATION; ALDEHYDES; TUBULIN; BINDING; KETONES; ENONES; ESTERS;

机译：DABCO催化二聚;微管聚合;共轭硝基烯烃;速率加速;醛;微管蛋白;结合;酮;烯酮;酯;

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The Morita-Baylis-Hillman adducts of beta-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies

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