Protonated N'-benzyl-N'-prolyl proline hydrazide as highly enantioselective catalyst for direct asymmetric aldol reaction

摘要

Protonated N'-benzyl-N'-L-prolyl-L-proline hydrazide has been developed as a highly enantioselective catalyst for the asymmetric direct aldol reaction of aromatic aldehydes with ketones.Proline catalysis in the asymmetric direct intermolecular aldol reactions has recently received extraordinary attention due to its fundamental importance to the evolution of so-called organoca-talysis.