Chlorodifluoromethyl phenyl sulfone: a novel non-ozone-depleting substance-based difluorocarbene reagent for O- and N-difluoromethylations

摘要

Chlorodifluoromethyl phenyl sulfone, a previously unknown compound that can be readily prepared from non-ODS-based precursors, was found to act as a robust difluorocarbene reagent for O- and N-difluoromerhylations. Selective introduction of fluorine atoms or fluorine-containing moieties into organic molecules is well-recognized as a powerful strategy to modulate the target molecules' physical, chemical and biological properties.