Bicyclic guanidine-catalyzed enantioselective phospha-Michael reaction: synthesis of chiral β-aminophosphine oxides and β-aminophosphines

摘要

Chiral bicyclic guanidine has been found to catalyze the phospha-Michael reactions of diaryl phosphine oxide to nitroalkenes with high enantioselectivities, offering a direct methodology to prepare chiral β-aminophosphine oxides and β-aminophosphines. Chiral compounds containing P-C bonds have found important synthetic roles in metal-catalyzed1 and organocatalytic reactions.