Aminophosphine phosphinites-new, its manufacturing process and its application to enantioselective reactions.

摘要

The invention relates to ligands phosphorus chiral FORMULAS: RY R '' IN (II), different from one another, are hydrocarbon radicals (alkyl, cycloalkyl, aryl, aralkyl or alkaryl); R is (III) is a hydrocarbon radical (alkyl, cycloalkyl or aryl); R (squared) = HO hydrocarbon radical, optionally bearing a function Co (II), AND CARRIER IN A FUNCTION CO (III); R 3 YR HIGH HIGH 4 necessarily be different, unless R 5 YR HIGH HIGH 6 are different, = H, hydrocarbon radical functionalised EVENTUALLY; R 5 YR HIGH HIGH 6 = HO EVENTUALLY functionalized hydrocarbon radical; (One of R 3 HIGH HIGH YR 4 can carry a FUNCTION -OPr SUB 2 O -nPr '2 -nPr SUB SUB 2); R (squared) 3 YR HIGH AND RESPECTIVELY NYC that lead may together form a heterocyclic ring; Or R (squared) YR HIGH 5, NYC that lead RESPECTIVELY AND INTERMEDIATE C can together form a heterocycle. Application in an enantioselective reaction (hydrogenation of carbonyl compounds for example).