Inclusion compounds of cystostatic active (C₅H₅)₂ VCl₂ and (CH₃C₅H₄)₂ VCl₂ with -, - and - cyclodextrines: Synthesis, EPR study and microbiological behavior toward Escherichia coli.

摘要

The inclusion of vanadocene dichloride (VDC) and 1,1'-dimethyl vanadocene dichloride (MeVDC) into cyclodextrines (-CD, -CD and -CD) was studied by EPR spectroscopy. It was found that VDC and MeVDC with -CD and -CD form true inclusion compounds, but with -CD, VDC and MeVDC gave only fine dispersion mixtures. The inclusion was validated by anisotropic EPR spectra of solid samples. In addition, the antimicrobial behavior (against E. coli) of each of the complexes was determined. It was established that not only did VDC and MeVDC cause elongation of E. coli, but also the new vanadocene inclusion complexes were effective in this regard.