Inclusion compounds of cystostatic active (C_5H_5)_2VCl_2 and(CH_3C_5H_4)_2VCl_2 with alpha-,beta- and gamma- cyclodextrines:Synthesis,EPR study and microbiological behavior toward Escherichia coli.

摘要

The inclusion of vanadocene dichloride(VDC)and 1,1'-dimethyl vanadocene dichloride(MeVDC)into cyclodextrines(alpha-CD, beta-CD and gamma-CD)was studied by EPR spectroscopy.It was found that VDC and MeVDC with beta-CD and gamma-CD form true inclusion compounds,but with alpha-CD,VDC and MeVDC gave only fine dispersion mixtures.The inclusion was validated by anisotropic EPR spectra of solid samples.In addition,the antimicrobial behavior(against E.coli)of each of the complexes was determined.It was established that not only did VDC and MeVDC cause elongation of E.coli,but also the new vanadocene inclusion complexes were effective in this regard.