ACE2 of the heart: From angiotensin I to angiotensin (1–7)

摘要

Angiotensin II (Ang II), a bioactive peptide of the renin–angiotensin system (RAAS), plays an important role in the development of cardiovascular diseases (CVD). Pharmacological inhibition of angiotensin-converting enzyme (ACE), the Ang II forming enzyme, or specific blockade of Ang II binding to angiotensin type 1 receptor (AT1R) through which it exerts its deleterious effects, were shown to provide some protection against progression of CVD.