Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics

摘要

Aims The aim of this study was to observe the direct physiological and biochemical cardiac effects in response to a newly identified putative component of the renin–angiotensin system, proangiotensin-12 (PA12); and investigate whether PA12 can serve as a substrate for Angiotensin II (AngII) generation.