Induction of MAPK phosphatase-1 by hypothermia inhibits TNF-α-induced endothelial barrier dysfunction and apoptosis

摘要

Aims Hypothermia therapy has been shown to confer robust protection against brain injury and cardiac arrest. However, the mechanisms underlying endothelial cell protection of hypothermia have not yet been completely elucidated. Here, we investigated molecular effects of hypothermia on tumour necrosis factor-α (TNF-α)-induced endothelial barrier dysfunction and apoptosis.