Necrostatin: A Potentially Novel Cardioprotective Agent?

Christopher C. T. Smith; Sean M. Davidson; Shiang Y. Lim; James C. Simpkin; John S. Hothersall; Derek M. Yellon

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Necrostatin: A Potentially Novel Cardioprotective Agent?

机译：坏死抑素：潜在的新型心脏保护剂？

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摘要

Necrostatin-1 (Nec-1), a small tryptophan-based molecule, was recently reported to protect the cerebral cortex against ischemia-reperfusion (I/R) injury. We investigated the actions of Nec-1 and its so-called inactive analog, Nec-1i, in the setting of myocardial I/R injury.

机译：Necrostatin-1（Nec-1）是一种基于色氨酸的小分子，最近被报道可以保护大脑皮层免于缺血再灌注（I / R）损伤。我们研究了Nec-1及其所谓的失活类似物Nec-1i在心肌I / R损伤中的作用。

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来源
《Cardiovascular Drugs and Therapy》 |2007年第4期|227-233|共7页
作者
Christopher C. T. Smith; Sean M. Davidson; Shiang Y. Lim; James C. Simpkin; John S. Hothersall; Derek M. Yellon;
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作者单位

The Hatter Cardiovascular Institute University College London Hospital and Medical School 67 Chenies Mews London WC1E 6HX UK;

The Hatter Cardiovascular Institute University College London Hospital and Medical School 67 Chenies Mews London WC1E 6HX UK;

The Hatter Cardiovascular Institute University College London Hospital and Medical School 67 Chenies Mews London WC1E 6HX UK;

The Hatter Cardiovascular Institute University College London Hospital and Medical School 67 Chenies Mews London WC1E 6HX UK;

The Hatter Cardiovascular Institute University College London Hospital and Medical School 67 Chenies Mews London WC1E 6HX UK;

The Hatter Cardiovascular Institute University College London Hospital and Medical School 67 Chenies Mews London WC1E 6HX UK;

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原文格式 PDF
正文语种 eng
中图分类
关键词
necrostatin; cardioprotection; infarct size; mitochondrial permeability transition pore;

机译：坏死抑制素;心脏保护作用;梗塞面积;线粒体通透性过渡孔;

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专利

1. The Cardioprotective Effect of Necrostatin Requires the Cyclophilin-D Component of the Mitochondrial Permeability Transition Pore [J] . S. Y. Lim, S. M. Davidson, M. M. Mocanu, Cardiovascular Drugs and Therapy . 2007,第6期

机译：坏死抑制素的心脏保护作用需要线粒体通透性转变孔的亲环素-D成分
2. Wortmannin, a Potent Antineutrophil Agent, Exerts Cardioprotective Effects in Myocardial Ischemia/Reperfusion Cardioprotective Effects in Myocardial Ischemia/Reperfusion [J] . YOUNG LINDON H. The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2000,第1aOcta期

机译：Wortmannin，一种有效的抗中性粒细胞药物，在心肌缺血/再灌注中具有心脏保护作用
3. Attenuation of cadmium-induced necrotic cell death by necrostatin-1: potential necrostatin-1 acting sites. [J] . Hsu TS, Yang PM, Tsai JS, Toxicology and Applied Pharmacology . 2009,第2期

机译：坏死抑制素-1减轻镉诱导的坏死细胞死亡：潜在的坏死抑制素1作用位点。
4. Hypoxia-inducible Factor 1 Alpha as a Cardioprotective Agent [C] . G. Valen, V. Martinov, J. Sagave, International Society for Heart Research . 2008

机译：缺氧诱导因子1α作为心脏保护剂
5. Nitrogen oxide releasing prodrugs as antiinflammatory, anticancer and cardioprotective agents [D] . Basudhar, Debashree 2011

机译：释放氮氧化物的前药，作为抗炎，抗癌和心脏保护剂
6. The cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore [O] . SY Lim, SM Davidson, MM Mocanu, -1

机译：坏死抑制素的心脏保护作用需要线粒体通透性过渡孔的亲环素D成分
7. The Cardioprotective Effect of Necrostatin Requires the Cyclophilin-D Component of the Mitochondrial Permeability Transition Pore [O] . S. Y. Lim, S. M. Davidson, M. M. Mocanu, 2007

机译：Necrostatin的心脏保护作用需要线粒体渗透性过渡孔的细胞素-D组分

Necrostatin: A Potentially Novel Cardioprotective Agent?

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