Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo

Cor H. J. Lamers; Sabine C. L. Langeveld; Corrien M. Groot-van Ruijven; Reno Debets; Stefan Sleijfer; Jan Willem Gratama

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Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo

机译：用于肾细胞癌过继免疫治疗的基因修饰T细胞在体内维持转基因特异性免疫功能

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We have treated three patients with carboxy-anhydrase-IX (CAIX) positive metastatic renal cell cancer (RCC) by adoptive transfer of autologous T-cells that had been gene-transduced to express a single-chain antibody-G250 chimeric receptor [scFv(G250)], and encountered liver toxicity necessitating adaptation of the treatment protocol. Here, we investigate whether or not the in vivo activity of the infused scFv(G250)+ T cells is reflected by changes of selected immune parameters measured in peripheral blood.

机译：我们已通过过继转移已被基因表达以表达单链抗体-G250嵌合受体[scFv（ G250）]，并且遇到肝脏毒性，因此必须调整治疗方案。在这里，我们研究了注入的scFv（G250）+ T细胞的体内活性是否通过外周血中所选免疫参数的变化反映出来。

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来源
《Cancer Immunology, Immunotherapy》 |2007年第12期|1875-1883|共9页
作者
Cor H. J. Lamers; Sabine C. L. Langeveld; Corrien M. Groot-van Ruijven; Reno Debets; Stefan Sleijfer; Jan Willem Gratama;
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作者单位

Laboratory for Clinical and Tumor Immunology Department of Medical Oncology Erasmus MC Daniel den Hoed Cancer Center PO Box 5201 3008 AE Rotterdam The Netherlands;

Laboratory for Clinical and Tumor Immunology Department of Medical Oncology Erasmus MC Daniel den Hoed Cancer Center PO Box 5201 3008 AE Rotterdam The Netherlands;

Laboratory for Clinical and Tumor Immunology Department of Medical Oncology Erasmus MC Daniel den Hoed Cancer Center PO Box 5201 3008 AE Rotterdam The Netherlands;

Laboratory for Clinical and Tumor Immunology Department of Medical Oncology Erasmus MC Daniel den Hoed Cancer Center PO Box 5201 3008 AE Rotterdam The Netherlands;

Department of Medical Oncology Erasmus MC Daniel den Hoed Cancer Center PO Box 5201 3008 AE Rotterdam The Netherlands;

Laboratory for Clinical and Tumor Immunology Department of Medical Oncology Erasmus MC Daniel den Hoed Cancer Center PO Box 5201 3008 AE Rotterdam The Netherlands;

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正文语种 eng
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关键词
Immunogene therapy; Human T lymphocytes; Single chain chimeric receptor; Renal cell cancer; Clinical study;

机译：免疫原疗法;人类T淋巴细胞;单链嵌合受体;肾细胞癌;临床研究;

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机译：使用异体自杀基因修饰的杀伤细胞对肝细胞癌采用过继免疫疗法的概念的体内证明。
2. An improved bicistronic CD20/tCD34 vector for efficient purification and in vivo depletion of gene-modified T cells for adoptive immunotherapy. [J] . Vogler I, Newrzela S, Hartmann S, Molecular therapy: the journal of the American Society of Gene Therapy . 2010,第7期

机译：一种改进的双顺反子CD20 / tCD34载体，用于有效纯化和体内消耗基因修饰的T细胞，用于过继免疫治疗。
3. Zoledronate facilitates large-scale ex vivo expansion of functional gamma delta T cells from cancer patients for use in adoptive immunotherapy [J] . Kondo M, Sakuta K, Noguchi A, Cytotherapy . 2008,第8期

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4. Vaccine-Primed Lymph Node Cells In the Adoptive Immunotherapy of Cancer: Presence of Host Immune Suppression Induced by Established Cancer [C] . Shuang Wei, Andrew B. Shreiner, Alfred E. Chang International Symposium on Cancer Metastasis and the Lymphovascular system: Basis for Rational Therapy . 2009

机译：癌症的疫苗引发淋巴结细胞：癌症的存在免疫抑制因成立癌症诱导
5. Harnessing calcium signaling in dendritic cells -- A potential approach to modulate the immune response in vivo for immunotherapy. [D] . Chan, Gail. 2013

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6. Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK–modified donor T cells after allogeneic hematopoietic cell transplantation [O] . Carolina Berger, Mary E. Flowers, Edus H. Warren, -1

机译：分析异基因造血细胞移植后限制过继转移的HSV-TK修饰的供体T细胞在体内持久性的转基因特异性免疫反应
7. Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo [O] . Cor H. J. Lamers, Sabine C. L. Langeveld, Corrien M. Groot-van Ruijven, 2007

机译：用于肾细胞癌过继免疫治疗的基因修饰T细胞在体内维持转基因特异性免疫功能

Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo

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