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Method for enhancing immune cell activity in vitro (Ex Vivo: Ex vivo) for cancer immunotherapy using small molecule ablation compounds

机译:使用小分子消融化合物增强用于癌症免疫治疗的体外免疫细胞活性的方法

摘要

Cancer immunotherapy in which “inducible immune anticancer agent” is induced in the host animal by intra-lesional (IL) administration of a halogenated xanthene tumor ablation compound into the solid tumor tumor of the host animal The method is disclosed. Samples of inductive immune anticancer agents are removed (collected) from the tumor-bearing host and stored as desired to form an immunologically effective concentrated tumor-specific immune anticancer agent composition. Cultured and selectively expanded. The composition is re-introduced into the host from which the predecessor inductive immune anticancer agent has been removed, or into another immunologically appropriate host in need of the composition. [Selection] Figure 1A
机译:通过将卤代x吨肿瘤消融化合物病灶内(IL)施用到宿主动物的实体瘤中,在宿主动物中诱导“诱导型免疫抗癌剂”的癌症免疫疗法。从携带肿瘤的宿主中移出(收集)诱导性免疫抗癌剂的样品,并根据需要进行储存,以形成免疫学上有效的浓缩的肿瘤特异性免疫抗癌剂组合物。培养并有选择地扩大。将该组合物重新引入已经从其上除去了先前的诱导免疫抗癌剂的宿主中,或重新引入需要该组合物的另一种在免疫学上合适的宿主中。 [选型]图1A

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