GABA<sub>A</sub> receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation

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GABA_A receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation

机译：GABA _{A 受体作为全身麻醉剂的分子靶标：结合位点的鉴定为变构调节提供了线索}

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Purpose The purpose of this review is to summarize current knowledge of detailed biochemical evidence for the role of γ-aminobutyric acid type A receptors (GABA_A–Rs) in the mechanisms of general anesthesia.

机译：目的这篇综述的目的是总结目前详细的生化证据，以了解γ-氨基丁酸A型受体（GABA _{A –Rs）在全身麻醉机制中的作用。}

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《Canadian Journal of Anesthesia / Journal canadien d'anesthésie》 |2011年第2期|p.206-215|共10页
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入库时间 2022-08-17 13:10:23

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1. GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation. [J] . Olsen RW, Li GD Canadian journal of anesthesia: Journal canadien d'anesthesie . 2011,第2期

机译：GABA（A）受体作为全身麻醉剂的分子靶标：结合位点的鉴定为变构调节提供了线索。
2. Comparison of alpha beta delta and alpha beta gamma GABA(A) receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics [J] . Feng Hua-Jun, Forman Stuart A. Pharmacological research: The official journal of The Italian Pharmacological Society . 2018,第期

机译：αβδ和αβγgaba（A）受体的比较：现场选择性全麻的亚单位安排的变构调制与鉴定
3. Possible allosteric binding site on Gyrase B, a key target for novel anti-TB drugs: homology modelling and binding site identification using molecular dynamics simulation and binding free energy calculations [J] . Chetty Sarentha, Soliman Mahmoud E. S. Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2015,第5期

机译：促旋酶B上可能的变构结合位点，这是新型抗结核药物的关键目标：使用分子动力学模拟和结合自由能计算进行同源性建模和结合位点鉴定
4. Equilibrium and kinetic allosteric mechanisms for anesthetic and structure function studies of GABA_A receptors [C] . Stuart A. Forma International Conference on Basic and Systemic Mechanisms of Anesthesia . 2005

机译：GABA_A受体麻醉与结构函数研究的平衡和动力学构想机制
5. Regulation of allosteric modulation of GABA(a) receptor function: Interaction between recombinant GABA(A) receptors and the novel anticonvulsant drug topiramate. [D] . Simeone, Timothy Anthony, Jr. 2003

机译：调节GABA（a）受体功能的变构调节：重组GABA（A）受体与新型抗惊厥药托吡酯之间的相互作用。
6. GABAA receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation [O] . Richard W. Olsen, Guo-Dong Li -1

机译：GABA A受体作为全身麻醉剂的分子靶标：结合位点的鉴定为变构调节提供了线索
7. GABAA receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation [O] . Olsen, Richard W., Li, Guo-Dong 2010

机译：GABA A受体作为全身麻醉剂的分子靶标：结合位点的鉴定为变构调节提供了线索
8. Identification of GABA (Gamma-Amino-Butyric Acid) Receptor Binding Sites in Insect Ganglia [R] . Lunt, G. G., Robinson, T. N., Miller, T., 1985

机译：鉴定昆虫神经节中的GaBa（γ-氨基 - 丁酸）受体结合位点

GABAA receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation

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GABA_A receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation