Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver

摘要

AIM To compare the effects of liposomes and glyco-poly-L-lysine on liver targeted uptake and METHODS After binding with lipofectamine or Galactose-terminal glyco-poly-L-lysine, the Plasmid could be expressed in eukaryotic cells When injected into Wistar rats by intravenous Route. At different time intervals after the injection, The distribution and expression of the plasmid in Liver of rats were observed and compared using in Situ hybridization and immunohistochemistry.