Protective effects of cyclosporine A on T-cell dependent ConA-induced liver injury in Kunming mice

摘要

The T-cell dependent specific liver injury in mice induced by concanavalin A (ConA) is a newly established experimental liver injury model, which is considered more eligible for the study of pathophysiology of several human liver diseases, such as viral hepatitis and autoimmune hepatitis~[1-9]. T cell activation and several cytokines release had been proven to play a critical role in ConA-induced liver injury~[10-19]. Cyclosprine A(CsA), an effective inhibitor of activation of T Lymphocyte, has been used widely in clinical treatment, Especially in autoimmune diseases and organ Transplantation~[20-25].