Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology

摘要

The mechanism that DNA hypomethylation leads to activation of oncogene and occurrence of malignant neoplasm is being increasingly recognized by researchers. Normal DNA methylation plays important role in stabilizing the phenotype of cell. DNA methylation status reduction and/or pattern Alteration are related to activation and abnormally High expression of some oncogenes and cellular Malignancy~[1-6].