Cell adhesion molecules

摘要

Cell adhesion molecules were first identified through their ability to allow cells to adhere to each other and to the extracellular matrix. We now know, however, that this group of cell surface receptors not only promotes adhesion but also allows cells to interact and communicate with each other and their environment and, in doing so, regulates a range of cell functions, including proliferation, gene expression, differentiation, apoptosis, and migration. A theme issue of Molecular Pathology, published this month, provides an opportunity to review work on cell adhesion, including its application to clinical practice.