Down-regulation of aortic and cardiac AT_1 receptor gene expression in transgenic (mRen-2) 27 rats

G.Nickenig; U.Laufs; P.S chnabel

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Down-regulation of aortic and cardiac AT_1 receptor gene expression in transgenic (mRen-2) 27 rats

机译：下调转基因（mRen-2）27大鼠的主动脉和心脏AT_1受体基因表达

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摘要

Together, the AT_1 receptor is down-regulated in TGR (mRen-2)27 rats in comparison to wildtype Sprague Dawley rats leading to a profoundly decreased response of cardiac and aortic tissue upon stimulation with angiotensin Ⅱ.

机译：总之，与野生型Sprague Dawley大鼠相比，TGR（mRen-2）27大鼠中的AT_1受体下调，导致血管紧张素Ⅱ刺激后心脏和主动脉组织的反应大大降低。

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《British Journal of Pharmacology》 |1997年第1期|p.134-140|共7页
作者
G.Nickenig; U.Laufs; P.S chnabel;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Angiotensin Ⅱ receptor; hypertension; cardiac hypertrophy;

机译：血管紧张素Ⅱ受体;高血压;心脏肥大;

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1. Comparative effects of the dual metallopeptidase inhibitor MDL 100,240 and of enalaprilat on regional and on cardiac haemodynamics in conscious, hypertensive, transgenic ((mRen-2)27) rats [J] . S.M.Gardiner, P.A.Kemp, F.Brunner-Ferber British Journal of Pharmacology . 1997,第8期

机译：双重金属肽酶抑制剂MDL 100,240和依那普利拉对有意识，高血压，转基因（（mRen-2）27）大鼠的局部和心脏血流动力学的比较作用
2. Effects of an AT_1 receptor antagonist, an ACE inhibitor and a calcium channel antagonist on cardiac gene expressions in hypertensive rats [J] . Shokei Kim, Kensuke Ohta, Akinori Hamaguchi, British Journal of Pharmacology . 1996,第3期

机译：AT_1受体拮抗剂，ACE抑制剂和钙通道拮抗剂对高血压大鼠心脏基因表达的影响
3. Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat [J] . Darren J Kelly, Sandford L Skinner, Richard E Gilbert, Kidney international. . 2000,第5期

机译：内皮素或血管紧张素II受体阻滞剂对转基因（mRen-2）27大鼠糖尿病的影响
4. Intra-Aortic Balloon Versus Extra-Aortic Counterpulsation In Severe Cardiac Failure Differences In Aortic Input Impedance And Left Ventricular Power Generation [C] . Zelano, J.A., Ko, . 2001

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5. T cell development and gamma/delta T cell antigen receptor: I. Structure and rearrangement of murine T cell antigen receptor delta chain gene. II. Expression of fetal type gamma/delta T cell receptor in adult transgenic mice and its effects on T cell development. [D] . Iwashima, Makio. 1990

机译：T细胞发育和γ/δT细胞抗原受体：I.鼠T细胞抗原受体δ链基因的结构和重排。二。胎儿型γ/δT细胞受体在成年转基因小鼠中的表达及其对T细胞发育的影响。
6. Down-regulation of aortic and cardiac AT1 receptor gene expression in transgenic (mRen-2) 27 rats [O] . G Nickenig, U Laufs, P Schnabel, 1997

机译：下调转基因（mRen-2）27大鼠的主动脉和心脏AT1受体基因表达
7. Down-regulation of aortic and cardiac AT1 receptor gene expression in transgenic (mRen-2) 27 rats [O] . Nickenig, G, Laufs, U, Schnabel, P, 1997

机译：下调转基因（mRen-2）27大鼠的主动脉和心脏AT1受体基因表达

Down-regulation of aortic and cardiac AT_1 receptor gene expression in transgenic (mRen-2) 27 rats

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