Comparative effects of the dual metallopeptidase inhibitor MDL 100,240 and of enalaprilat on regional and on cardiac haemodynamics in conscious, hypertensive, transgenic ((mRen-2)27) rats

摘要

These results are more consistent with the antihypertensive effects of enalaprilat or MDL 100, 240 in transgenic ((mRen-2)27) rats being due to suppression of angiotensin Ⅱ production, than due to inhibition of bradykinin degradation. The additional effects of MDL 100, 240 may be accounted for by inhibition of the degradation of natriuretic peptides reducing cardiac output, initially, and decreasing vascular tone, subsequently.