Suppression of macrophage inflammatory protein(MIP)-1α production and collagen-induced arthritis by adenosine receptor agonists

摘要

Ligands of the various adenosine receptor subtypes modulate the production of pro-and anti- inflammatory cytokines. Here we evaluated the effect of adenosine and various ligands of the adenosine receptor subtypes (A_1, A_2, A_3) on the chemokine macrophage inflammatory protein(MIP) 1α production in immunostimulated RAW macrophages in vitro. Furthermore, we studied whether a selected A_3 adenosine receptor agonist inhibits MIP-1α production and affects the course of inflammation in collagen-induced arthritis.