Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic rate during longterm endotoxin-induced shock in pigs

摘要

We investigated hepatic blood flow, O_2 exchange and metabolism in porcine endotoxic shock (Control, n =8; Endotoxin, n =10) with administration of hydroxyethylstarch to maintain arterial pressure (MAP)>60 mmHg. Before and 12, 18 and 24 h after starting continuous i.v. endotoxin we measured portal venous And hepatic arterial blood flow, intracapillary haemoglobin O_2 saturation (Hb-O_2/100) of the liver Surface and arterial, portal and hepatic venous lactate, pyruvate, glyercol and alanine concentrations. Glucose production rate was derived from the plasma isotope enrichment during infusion of [6,6-~2H_2]- Glucose.