Presynaptic inhibition preferentially reduces the NMDA receptor-mediated component of transmission in rat midbrain dopamine neurons

摘要

1. We used patch pipettes to record whole-cell currents from single dopamine neurons in slices of rat midbrain. Pharmacological methods were used to isolate EPSCs evoked by focal electrical stimulation. 2. Baclofen was significantly more potent for inhibiting NMDA receptor-mediated ESCs (IC_50 = 0.24 μM) compared with inhibition of EPSCs mediated by AMPA receptors (IC_50 = 1.72 μM).