Effect of protein kinase A inhibitors on the production of Aβ40 and A β_42 by human cells expressing normal and Alzheimer's Disease-linked mutated βAPP and presenilin 1

摘要

1. We previously established that the formation of both α-and β/γ-secretase-derived products generated by human embryonic kidney 293 cells (HEK293) expressing either wild type or mutant βAPP could be stimulated by agonists of the cyclic AMP/protein kinase A pathways. This cyclic AMP-dependent effect modulates post-translational events since it is not prevented by actinomycin D or cycloheximide.