Endogenous nitric oxide in the maintenance of rat microvascular integrity against widespread plasma leakage following abdominal laparotomy

摘要

1. The role of nitric oxide (NO) in the maintenance of microvascular integrity during minor surgical manipulation has been evaluated in the rat. 2. The NO synthase inhibitors, N~G-methyl ester (L-NAME, 5 mg kg~-1, s. c.) and N~G-monomethyl-L-arginine (L-NMMA, 50 mg kg`-1, S. C.)had no effect on microvascular leadage of Radiolabelled albumin over 1 h in the stomach, duodenum, jejunum, colon, lung and kidney in the Un-operated conscious or pentobarbitone-anaesthetized rat.