ECL-cell histamine mobilization in conscious rats: effects of locally applied regulatory peptides, candidate neurotransmitters and inflammatory mediators

摘要

The ECL cells control gastric secretion by mobilizing histamine in response to circulating gastrin. In addition, the ECL cells are thought to operate under nervous control and to be influenced by local inflammatory processes. The purpose of the present study was to monitor histamine mobilization from ECL cells in Conscious rats in response to locally applied regulatory peptides, candidate neurotransmitters and Inflammatory mediators. Microdialysis probes were implanted in the submucosa of the acid-producing part of the rat Stomach.