Mobilization of rat stomach ECL-cell histamine in response to short-to long-term treatment with omeprazole and/or YF 476 studied by gastric submucosal microdialysis in conscious rats

摘要

Mobilization of histamine from the ECL cells was monitored by gastric submucosal microdialysis in conscious rats. The ECL cells are known to operate under gastrin control and the purpose of the present study was to examine their in situ response to short-term(12 h)as well as long-term(28 days)hypergastrinaemia, induced by treatment with the porton pump inhibitor omeprazole. Hypergastrinaemia promptly raised the histamine concentration in the microdialysate. The effect Was prevented by CCK_2 receptor blockade(YF476).