Analysis of S-nitroso-N-acetylpenicillamine effects on dopamine release in the striatum of freely moving rats: role of endogenous ascorbic acid and oxidative stress

摘要

We showed previously that interaction between NO and iron(Ⅱ), both released following decomposition of sodium nitroprusside(SNP), accounted for the late SNP-induced dopamine(DA) increase in dialysates from the stratum of freely moving rats. In this study, intrastriatal infusion of the NO-donor S-nitroso-N-acetylpenicillamine(SNAP) (0.2 mM for 180 min)induced a moderate increase in dialysate DA and decreases in ascorbic acid dialysate concentrations; in contrast, SNAP 1 mM infusion induced a long-lasting decreased in both DA and ascorbic acid dialysate concentrations.