Role of bradykinin in preconditioning and protection of the ischaemic myocardium

摘要

Bradykinin exerts a unique and robust pattern of injury limiting actions in the ischaemic and reperfused heart. A wealth of evidence suggests that dradykinin administered prior to the onset of myocardial ischaemia exerts a cardioprotective effect in animal and human experimental models. Endogenous bradykinin participates in classical preconditioning in many experimental models. Recently, a potential role for bradykinin in eliciting a delayed phase of preconditioning has emerged. Bradykinin has also been shown to limit reperfusion injury, an action which may be beneficial in patients receiving reperfusion therapy for acute myocardial infarction.