Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours

G. Martín-Ezquerra; R. Salgado; A. Toll; M. Gilaberte; T. Baró; F. Alameda Quitllet; M. Yébenes; F. Solé; M. Garcia-Muret; B. Espinet; R.M. Pujol

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Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours

机译：口腔鳞状细胞癌的多种基因拷贝数改变：原发性和转移性肿瘤中MYC，TP53，CCDN1，EGFR和ERBB2状态的研究

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SummaryBackground Oncogenesis in the oral cavity is believed to result from genetic alterations that cause a stepwise transformation of the mucosa to invasive carcinoma. In oral squamous cell carcinoma (OSCC) multiple cytogenetic abnormalities have been reported, but their practical significance remains uncertain.

机译：总结背景口腔中的肿瘤发生被认为是由引起粘膜逐步转化为浸润性癌的遗传改变引起的。在口腔鳞状细胞癌（OSCC）中，已报告了多种细胞遗传学异常，但其实际意义仍不确定。

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来源
《British Journal of Dermatology》 |2010年第5期|p.1028-1035|共8页
作者
G. Martín-Ezquerra; R. Salgado; A. Toll; M. Gilaberte; T. Baró; F. Alameda Quitllet; M. Yébenes; F. Solé; M. Garcia-Muret; B. Espinet; R.M. Pujol;
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作者单位

Department of Medicina i Dermatologia, Universitat Autònoma de Barcelona, Hospital del Mar, Parc de Salut Mar, Passeig Marítim 25–29, 08003 Barcelona, Spain;

Molecular Cytogenetics Laboratory, Department of Pathology, IMIM-Hospital del Mar, Barcelona, Spain;

Department of Medicina i Dermatologia, Universitat Autònoma de Barcelona, Hospital del Mar, Parc de Salut Mar, Passeig Marítim 25–29, 08003 Barcelona, Spain;

Department of Medicina i Dermatologia, Universitat Autònoma de Barcelona, Hospital del Mar, Parc de Salut Mar, Passeig Marítim 25–29, 08003 Barcelona, Spain;

Molecular Cytogenetics Laboratory, Department of Pathology, IMIM-Hospital del Mar, Barcelona, Spain;

Molecular Cytogenetics Laboratory, Department of Pathology, IMIM-Hospital del Mar, Barcelona, Spain;

Department of Dermatology, Consorci Sanitari Parc Taulí, Barcelona, Spain;

Molecular Cytogenetics Laboratory, Department of Pa;

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正文语种 eng
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关键词
carcinogenesis; carcinoma; CCND1; EGFR; ERBB2; squamous cell; TP53;

机译：癌变;癌;CCND1;EGFR;ERBB2;鳞状细胞;TP53;

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专利

1. Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours. [J] . Martin Ezquerra G, Salgado R, Toll A, British Journal of Dermatology . 2010,第5期

机译：口腔鳞状细胞癌的多种基因拷贝数改变：原发性和转移性肿瘤中MYC，TP53，CCDN1，EGFR和ERBB2状态的研究。
2. EGFR copy number alterations in primary tumors, metastatic lymph nodes, and recurrent and multiple primary tumors in oral cavity squamous cell carcinoma [J] . Shiang-Fu Huang, Huei-Tzu Chien, Sou-De Cheng, BMC Cancer . 2017,第1期

机译：口腔鳞状细胞癌中原发性肿瘤，转移性淋巴结以及复发性和多发性原发性肿瘤的EGFR拷贝数变化
3. MYC, TP53, and Chromosome 17 Copy-Number Alterations in Multiple Gastric Cancer Cell Lines and in Their Parental Primary Tumors [J] . Mariana Ferreira Leal, Danielle Queiroz Calcagno, Joana de Fatima Ferreira Borges da Costa, Journal of biomedicine & biotechnology . 2011,第Cytogenetics期

机译：MYC，TP53和染色体17拷贝数变化在多个胃癌细胞系及其父母原发性肿瘤中
4. Increased expression of Toll-like receptor-9 has close relation with tumour cell proliferation in oral squamous cell carcinoma [C] . Ruan Min, Zhang Zun, Li Siyi, Academic Committee Conference of Shanghai key lab of stomatology . 2011

机译：Toll样受体9表达的增加与口腔鳞状细胞癌中肿瘤细胞的增殖密切相关
5. The correlation between tumour volume and survival in oral cavity and oropharyngeal squamous cell carcinoma. [D] . Anand, Sumeet M. 2009

机译：口腔和口咽鳞状细胞癌的肿瘤体积与生存率的关系。
6. EGFR copy number alterations in primary tumors metastatic lymph nodes and recurrent and multiple primary tumors in oral cavity squamous cell carcinoma [O] . Shiang-Fu Huang, Huei-Tzu Chien, Sou-De Cheng, 2017

机译：口腔鳞状细胞癌中原发性肿瘤转移性淋巴结以及复发性和多发性原发性肿瘤的EGFR拷贝数变化
7. MYC, TP53, and Chromosome 17 Copy-Number Alterations in Multiple Gastric Cancer Cell Lines and in Their Parental Primary Tumors [O] . Leal Mariana Ferreira, Calcagno Danielle Queiroz, Ferreira Borges da Costa Joana de Fatima, 2011

机译：MYC，TP53和染色体17拷贝数变化在多个胃癌细胞系及其父母原发性肿瘤中

Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours

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