Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria

Bassam Lajin; Abdul Rezzak Hamzeh; Lina Ghabreau; Ali Mohamed; Ala-Eddin Al Moustafa; Amal Alachkar

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Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria

机译：儿茶酚-O-甲基转移酶Val 108/158 Met多态性与乳腺癌风险：叙利亚的病例对照研究

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Background Catechol-O-methyltransferase (COMT) inactivates catechol estrogens by methylation and thus may play a protective role against mutations induced by estrogen metabolites. In this study we investigated the relationship between the Vall58Met polymorphism in the COMT gene and breast cancer risk in a population-based case control study in Syria.

机译：背景儿茶酚-O-甲基转移酶（COMT）通过甲基化使儿茶酚雌激素失活，因此可能对由雌激素代谢物引起的突变起保护作用。在这项研究中，我们在叙利亚一项基于人群的病例对照研究中，研究了COMT基因中Vall58Met多态性与乳腺癌风险之间的关系。

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来源
《Breast Cancer》 |2013年第1期|62-66|共5页
作者
Bassam Lajin; Abdul Rezzak Hamzeh; Lina Ghabreau; Ali Mohamed; Ala-Eddin Al Moustafa; Amal Alachkar;
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作者单位

Department of Pharmacology Cancer Research Lab Faculty of Pharmacy University of Aleppo">(1);

Department of Pharmacology Cancer Research Lab Faculty of Pharmacy University of Aleppo">(1);

Pathology Department Faculty of Medicine University of Aleppo">(2);

Oncosurgery Ibn Rushd Hospital">(3);

Department of Pharmacology Cancer Research Lab Faculty of Pharmacy University of Aleppo">(1);

Research Cancer Centre of the Syrian Society Against Cancer">(4);

Oncology Department Faculty of Medicine McGill University">(5);

Department of Pharmacology Cancer Research Lab Faculty of Pharmacy University of Aleppo">(1);

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原文格式 PDF
正文语种 eng
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关键词
Breast cancer; Syrian patients; COMT; Val158Met; Polymorphism;

机译：乳腺癌;叙利亚病人;COMT;Val158Met;多态性;

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专利

1. Lack of association between catechol-O-methyltransferase Val108/158Met polymorphism and breast cancer risk: a meta-analysis of 25,627 cases and 34,222 controls [J] . Chen Mao, Xi-Wen Wang, Li-Xin Qiu, Breast Cancer Research and Treatment . 2010,第3期

机译：儿茶酚-O-甲基转移酶Val108 / 158Met多态性与乳腺癌风险之间缺乏关联：对25,627例病例和34,222例对照的荟萃分析
2. Catechol-O-methyltransferase Val 108/158 Met polymorphism in premenopausal breast cancer patients. [J] . Sazci A, Ergul E, Utkan NZ, Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems . 2004,第2a3期

机译：绝经前乳腺癌患者的儿茶酚-O-甲基转移酶Val 108/158 Met多态性。
3. Interaction between catechol-O-methyltransferase (COMT) Val108/158Met and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in age at onset and clinical symptoms in schizophrenia. [J] . Numata S, Ueno S, Iga J, Journal of neural transmission . 2007,第2期

机译：精神分裂症发病年龄和临床症状中儿茶酚-O-甲基转移酶（COMT）Val108 / 158Met与脑源性神经营养因子（BDNF）Val66Met多态性之间的相互作用。
4. A fully-automated software pipeline for integrating breast density and parenchymal texture analysis for digital mammograms: Parameter optimization in a case-control breast cancer risk assessment study [C] . Yuanjie Zheng, Yan Wang, Brad M. Keller, Conference on computer-aided diagnosis . 2013

机译：整合了乳腺密度和实质性纹理分析以进行数字化X线检查的全自动软件管道：病例对照乳腺癌风险评估研究中的参数优化
5. Catechol-O-methyltransferase polymorphism: Effects on catechol estrogen methylation and breast cancer risk [D] . Goodman, Julie Elizabeth 2002

机译：儿茶酚-O-甲基转移酶多态性：对儿茶酚雌激素甲基化和乳腺癌风险的影响
6. The Catechol-O-Methyltransferase Val158Met Polymorphism Contributes to the Risk of Breast Cancer in the Chinese Population: An Updated Meta-Analysis [O] . Guo-Xing Wan, Yu-Wen Cao, Wen-Qin Li, 2014

机译：儿茶酚-O-甲基转移酶Val158Met多态性有助于中国人群患乳腺癌的风险：最新的荟萃分析
7. Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence [O] . Nedić Gordana, Nikolac Matea, Nenadić Šviglin Korona, 2011

机译：酒精依赖患者功能性儿茶酚-O-甲基转移酶（COMT）Val108 / 158Met多态性与自杀企图的关联研究

Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria

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