Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression

Göran Landberg; Kristina Nilsson; Karin Jirström; Lisa Rydén; Richard Kitching; Angelika M. Burger; Arun Seth

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Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression

机译：细胞周期蛋白I在人类乳腺癌中表达，并与VEGF和KDR表达密切相关

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In the present study, cyclin I protein expression in 114 invasive human breast cancers was correlated with cell cycle and angiogenesis-related proteins and clinico-pathological data. A strong association was found between cytoplasmic cyclin I staining and VEGF (p = 0.001) as well as the VEGF receptor KDR (p = 0.001), suggesting a link between cyclin I and angiogenesis.

机译：在本研究中，cyclin I蛋白在114例浸润性人类乳腺癌中的表达与细胞周期和血管生成相关蛋白以及临床病理数据相关。发现细胞质细胞周期蛋白I染色与VEGF（p = 0.001）以及VEGF受体KDR（p = 0.001）之间有很强的联系，这表明细胞周期蛋白I与血管生成之间存在联系。

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来源
《Breast Cancer Research and Treatment》 |2005年第3期|313-316|共4页
作者
Göran Landberg; Kristina Nilsson; Karin Jirström; Lisa Rydén; Richard Kitching; Angelika M. Burger; Arun Seth;
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作者单位

Division of Pathology Department of Laboratory Medicine U-MAS Lund University;

Division of Pathology Department of Laboratory Medicine U-MAS Lund University;

Division of Pathology Department of Laboratory Medicine U-MAS Lund University;

Division of Pathology Department of Laboratory Medicine U-MAS Lund University;

Department of Laboratory Medicine and Pathobiology Laboratory of Molecular Pathology and Sunnybrook and Women’s College Health Sciences Centre University of Toronto;

Department of Laboratory Medicine and Pathobiology Laboratory of Molecular Pathology and Sunnybrook and Women’s College Health Sciences Centre University of Toronto;

Department of Laboratory Medicine and Pathobiology Laboratory of Molecular Pathology and Sunnybrook and Women’s College Health Sciences Centre University of Toronto;

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正文语种 eng
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breast cancer; cyclin I; proliferation; VEGF;

机译：乳腺癌;细胞周期蛋白I;增殖;VEGF;

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专利

1. Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression. [J] . Landberg G, Nilsson K, Jirstrom K, Breast cancer research and treatment. . 2005,第3期

机译：细胞周期蛋白I在人类乳腺癌中表达，并与VEGF和KDR表达密切相关。
2. A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model. [J] . Zhang W, Ran S, Sambade M, Angiogenesis . 2002,第1a2期

机译：阻断VEGF与VEGFR2结合的单克隆抗体（KDR / Flk-1）在原位人类乳腺癌模型中抑制Flk-1的血管表达和肿瘤生长。
3. High level expression of p27~kip1 and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27~kip1 and degree of malignancy in human breast and colorectal cancers [J] . Steffen Fredersdorf, Jorges Burns, Alistair M. Milne Proceedings of the National Academy of Sciences of the United States of America . 1997,第12期

机译：p27〜kip1和cyclin D1在某些人乳腺癌细胞中的高表达：p27〜kip1表达与人乳腺癌和大肠癌的恶性程度呈负相关
4. Curcumin inhibits vascular endothelial growth factor (VEGF) expression on a murine triple-negative breast cancer [C] . Retno Murwanti, Azmi Rahmadani, Adam Hermawan, International Conference on Biological Science . 2020

机译：姜黄素抑制鼠三阴性乳腺癌上的血管内皮生长因子（VEGF）表达
5. The role of NRF2 on VEGFA/VEGFR expression, hepatic vascularization and cancer growth. [D] . Skoko, John J., III. 2013

机译：NRF2对VEGFA / VEGFR表达，肝血管生成和癌症生长的作用。
6. Production of VEGF and expression of the VEGF receptors Flt-1 and KDR in primary cultures of epithelial and stromal cells derived from breast tumours [O] . V Speirs, S L Atkin 1999

机译：乳腺肿瘤来源的上皮和基质细胞原代培养物中VEGF的产生及VEGF受体Flt-1和KDR的表达
7. Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression [O] . Landberg, Göran, Nilsson, Kristina, Jirström, Karin, 2005

机译：细胞周期蛋白I在人乳腺癌中表达，与VEGF和KDR表达密切相关

Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression

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