Die Chemische Biologie beschreitet neue Wege in der Chromatinforschung Histonmodifikation

摘要

Histones package DNA into chromatin and regulate genes through a multitude of histone modifications. A ‘histone code’ hypothesis has been put forth that ascribes different patterns of histone modifications specific biological functions. This article highlights recent chemical biological approaches to uncover the complex cross-talk between histone marks and chromatin activity.