NEUE IMIDAZO- UND TRIAZOLO-THIADIAZINE VERFAHREN ZU IHRER HERSTELLUNG DIE SIE ENTHALTENDEN ARZNEIMITTEL UND IHRE VERWENDUNG SOWIE EINIGE BEI DER HERSTELLUNG DER GENANNTEN VERBINDUNGEN GEBILDETE ZWISCHENPRODUKTE

摘要

Imidazo- and triazolothiadiazines of the formula I …IMAGE… in which R1 = C1-C4-alkyl,… R2 = H or C1-C3-alkyl… and the structural element -A-B-… = -CH2-CH2-, -CH=CH-, -CH=N-, -CH2-CO- or -CO-CH2-,… and their physiologically tolerable acid addition salts are prepared by reaction of 2-halo-1-phenylalkanones of the formula II …IMAGE… with compounds of the formula III …IMAGE… and, if desired, conversion of the compounds of the formula I formed into their physiologically tolerable acid addition salts by means of suitable acids. …??The compounds of the formula I and their physiologically tolerable acid addition salts are mainly suitable for the prevention and treatment of inflammatory diseases - in particular of inflammatory rheumatic diseases. …??Some of the intermediates formed during the preparation of the compounds of the formula I are also new, i.e. 1-amino- 2-mercaptoimidazole …IMAGE… and 1-amino-2-thioxo-5-imidazolidinone …IMAGE…