A computational model-based approach for atlas construction of aortic Doppler velocity profiles for segmentation purposes

摘要

Highlights•A framework that couples circulation model and atlas construction method is proposed.•The model quickly simulates virtual patients with diverse conditions of aortic valve.•Their Doppler images are obtained via fluid dynamics and imaging modality properties.•The atlas created from simulated images was applied for segmenting clinical images.•Applied atlas construction method proves favorable for heterogeneous conditions.AbstractEchocardiography is the leading imaging modality for cardiac disorders in clinical practice. During an echocardiographic exam, geometry and blood flow are quantified in order to assess cardiac function. In clinical practice, these image-based measurements are currently performed manually. An automated approach is needed if more advanced analysis is desired.In this article, we propose a new hybrid framework for the construction of a disease-specific atlas to improve Doppler aortic outflow velocity profile segmentation. The proposed method is based on combining realistic computational simulations of the cardiovascular system for common cardiac conditions (using CircAdapt) with a validated image-based atlas construction method. The coupling is realized via model-based generation of echocardiographic images of virtual populations with a statistically approved parameter variation. We created virtual populations of 100 healthy individuals and 100 patients with aortic stenosis, synthesized their aortic Doppler velocity images and constructed the corresponding atlases. We validated atlases’ performances by comparing their segmentation of real clinical images with the manually segmented ground truth. The experimental results show that the segmentation accuracy obtained using the proposed atlases is comparable to the accuracy obtained using classical clinical image-based atlases. Moreover, this framework eliminates the time-consuming acquisition of a sufficient number of representative images in clinical practice, offering a substantial time efficiency and flexibility in creating a disease specific atlas and ensuring an observer-independent automated segmentation. The proposed approach can easily be extended towards the creation of atlases for segmenting any Doppler trace in the cardiovascular circulation in a specific disease.