Improved peak detection in mass spectrum by incorporating continuous wavelet transform-based pattern matching

摘要

Motivation: A major problem for current peak detection algorithms is that noise in mass spectrometry (MIS) spectra gives rise to a high rate of false positives. The false positive rate is especially problematic in detecting peaks with low amplitudes. Usually, various baseline correction algorithms and smoothing methods are applied before attempting peak detection. This approach is very sensitiveto the amount of smoothing and aggressiveness of the baseline correction, which contribute to making peak detection results inconsistent between runs, instrumentation and analysis methods.