Influnce of culture conditions on the α1,2-fucosyltransferase and MUC gene expression of a transformed cell line MM-39 derived From human tracheal gland cells

摘要

Human tracheal glands cells(HTGC)in culture are able to respond to adrenergic, cholinergic and purinergic agonists by increasing their serous and mucin secretions. These secretagogues are also able to maintain a optimal responsiveness of serous cells to stimulation when they are regularly and briefly to the cells, making the HTGC a suitable model to study the serous secretion(Merten, in press). Our interest has been focused on the effects of cholinergic and purinergic secretagogues associated to histamine, on the mucous function of the transformed human tracheal gland cell line MM-39, which has a mixed, both serous and mucous, phenotype.