Retinoid X receptor (RXRα) gene expression is regulated by fatty acids and dexamethasone in hepatic cells

摘要

This work describes the molecular mechanism of fatty acid and hormonal modulation of retinoid X receptor (RXRα) in rat liver. We examined the effects of different fatty acids (myristic-, stearic-, linolenic-, oleic- and tetradecylthioacetic acid (TTA)) and the synthetic glucocorticoid dexamethasone on RXRα mRNA and protein steady-state levels in hepatoma cells and cultured hepatocytes.