The effects of androgen on penie reflex, erectly response to electrical stimulation and penile NOS activity in the rat

摘要

To investigate the effects of androgen on penile erection through the reflex arc and penile corpus cavernosum, and study the respective roles of testosterone (T) and dihydrotestosterone (DHT) in peinle erection in rats. Methods: Mae Sprague-Dawley rats were castrated and implanted with silastic brand silincone tube containing T or DHT, with or without daily injections of a 5α-reeducates inhibitor, MK-434. The penile reflex, erectly response to electrical stimulation (ES) of the cavernous nerves and penny nitric-oxide syntheses (NOS) activity were observed under varying androgenic status. Results: Penile reflex erection in the rat was, on the whole, related to serum T levels though the number of glans engagements was not. The number of cups and flips was significantly decreased by castration, and restored to the control level by T supplementation. Erectly response to ES and NOS activity in penile tissue was also related to serum T level. T administered together with a 5α-reeducates inhibitor no longer restored the number of refax erection, erectly responses to ES and NOS activity in the corpus cavernous. Conclusion: Androgen influenced the penile reflex arc, corpus cavernous, and the perineal striated muscles. In reflex erection, erectly response to ES and penile NOS activity in the rat, T seems to be first converted to DHT, the more active androgen moderate.