Biodegradable microspherical implants containing teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis

Zafer Orhan; Erdal Cevher; Ayca Yıldız; Rengin Ahıskalı; Demet Sensoy; Lütfiye Mülazımoğlu

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Biodegradable microspherical implants containing teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis

机译：含有替考拉宁的可生物降解的微球植入物，用于治疗耐甲氧西林的金黄色葡萄球菌骨髓炎

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Background The aim of this study was to prepare poly(d,l-lactide-co-glycolide) (PLGA) microspherical implants containing teicoplanin (TCP) using a double emulsion solvent evaporation method and to evaluate its efficacy for the local treatment of chronic osteomyelitis.

机译：背景本研究的目的是使用双乳剂溶剂蒸发法制备包含替考拉宁（TCP）的聚（d，l-丙交酯-乙交酯）共聚物（PLGA）微球形植入物，并评估其在局部治疗慢性骨髓炎中的功效。。

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来源
《Archives of Orthopaedic and Trauma Surgery》 |2010年第1期|p.135-142|共8页
作者
Zafer Orhan; Erdal Cevher; Ayca Yıldız; Rengin Ahıskalı; Demet Sensoy; Lütfiye Mülazımoğlu;
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正文语种 eng
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关键词
TCP–PLGA implants; Osteomyelitis; MRSA;

机译：TCP-PLGA植入物;骨髓炎;MRSA;

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专利

1. Comparison of Borate Bioactive Glass and Calcium Sulfate as Implants for the Local Delivery of Teicoplanin in the Treatment of Methicillin-Resistant Staphylococcus aureus-Induced Osteomyelitis in a Rabbit Model [J] . Jia Wei-Tao, Fu Qiang, Huang Wen-Hai, Antimicrobial agents and chemotherapy. . 2015,第12期

机译：硼酸盐生物活性玻璃和硫酸钙植入替考拉宁局部治疗耐甲氧西林金黄色葡萄球菌诱导的骨髓炎的兔子模型的比较
2. In vitro and in vivo efficacies of teicoplanin-loaded calcium sulfate for treatment of chronic methicillin-resistant Staphylococcus aureus osteomyelitis. [J] . Jia WT, Luo SH, Zhang C Antimicrobial agents and chemotherapy. . 2010,第1期

机译：替考拉宁加载的硫酸钙的体外和体内治疗慢性耐甲氧西林的金黄色葡萄球菌骨髓炎的疗效。
3. Characterization of biodegradable chitosan microspheres containing vancomycin and treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with prepared microspheres. [J] . Cevher E, Orhan Z, Mulazimoglu L, International Journal of Pharmaceutics . 2006,第2期

机译：含万古霉素的可生物降解的壳聚糖微球的表征，并用已制备的微球治疗耐甲氧西林的金黄色葡萄球菌引起的实验性骨髓炎。
4. In Vivo Assessment of Titanium Devices loaded with gentamicin in a methicillin-resistant Staphylococcus aureus Rabbit Osteomyelitis Experimental Model [C] . Gilles Amador, Loic Pichavant, Helene Carrie, European conference on biomaterials . 2014

机译：在耐甲氧西林金黄色葡萄球菌兔骨髓炎实验模型中负载庆大霉素的钛装置的体内评估
5. Evaluation of Anti-Glucosaminidase Monoclonal Antibodies as a Passive Vaccination for Implant-Associated Staphylococcus aureus Osteomyelitis [D] . Varrone, John Joseph Perry 2014

机译：评价抗葡萄糖苷酶单克隆抗体作为与植株相关的金黄色葡萄球菌骨髓炎的被动疫苗
6. Comparison of Borate Bioactive Glass and Calcium Sulfate as Implants for the Local Delivery of Teicoplanin in the Treatment of Methicillin-Resistant Staphylococcus aureus-Induced Osteomyelitis in a Rabbit Model [O] . Wei-Tao Jia, Qiang Fu, Wen-Hai Huang, 2015

机译：硼酸盐生物活性玻璃和硫酸钙植入替考拉宁局部治疗耐甲氧西林金黄色葡萄球菌诱导的骨髓炎的兔子模型的比较
7. Long-term Treatment of Teicoplanin for Methicillin-resistant Staphylococcus aureus Sternal Osteomyelitis with Renal Impairment: A Case of High Teicoplanin Trough Levels Maintained by Therapeutic Drug Monitoring [O] . Hideo Shiohira, Masashi Nakamatsu, Yuya Kise, 2016

机译：用于甲氧西林的丁香蛋白的长期治疗抗性金黄色葡萄球菌具有肾损伤的胸骨骨髓炎：通过治疗药物监测维持的高茶蛋白槽水平的情况

Biodegradable microspherical implants containing teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis

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